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Affinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody Interface
Authors:Takefumi Yamashita  Eiichi Mizohata  Satoru Nagatoishi  Takahiro Watanabe  Makoto Nakakido  Hiroko Iwanari  Yasuhiro Mochizuki  Taisuke Nakayama  Yuji Kado  Yuki Yokota  Hiroyoshi Matsumura  Takeshi Kawamura  Tatsuhiko Kodama  Takao Hamakubo  Tsuyoshi Inoue  Hideaki Fujitani  Kouhei Tsumoto
Affiliation:1. Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan;2. Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan;3. Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan;4. Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan;5. Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan;6. Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan
Abstract:
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  • Keywords:antibody  protein-protein interaction  affinity improvement  interfacial water  salt bridge  ROBO1  B5209B  X-ray crystallography  isothermal titration calorimetry  molecular dynamics
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