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BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation
Authors:Dali Zong  Salomé Adam  Yifan Wang  Hiroyuki Sasanuma  Elsa Callén  Matilde Murga  Amanda Day  Michael J. Kruhlak  Nancy Wong  Meagan Munro  Arnab Ray Chaudhuri  Baktiar Karim  Bing Xia  Shunichi Takeda  Neil Johnson  Daniel Durocher  André Nussenzweig
Affiliation:1. Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA;2. The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada;3. Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, USA;4. Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan;5. Genomic Instability Group, Spanish National Cancer Research Center, CNIO, Madrid, Spain;6. Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA;7. Department of Molecular Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands;8. Pathology/Histotechnology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA;9. Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA;10. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
Abstract:
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  • Keywords:chromatin ubiquitylation  homologous recombination  cancer  RNF168  BRCA1  PALB2  RAD51  haploinsufficiency  genome stability  resection  replication fork protection
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