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A mutant telomerase defective in nuclear‐cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction
Authors:Olga A Kovalenko  Matthieu J Caron  Perihan Ulema  Carolina Medrano  Andrew P Thomas  Masayuki Kimura  Marcelo G Bonini  Utz Herbig  Janine H Santos
Institution:1. Department of Pharmacology and Physiology;2. Department of Pathology;3. Department of Pediatrics;4. Laboratory of Pharmacology, National Institute of Environmental and Health Sciences, 111 TW Alexander dr, MD F0‐02, Durham, NC 27709, USA;5. Present address: Section of Cardiology/Department of Pharmacology, University of Illinois at Chicago. 909 South Wolcott Ave, COMRB 3020, Chicago, IL 60612, USA;6. Department of Microbiology and Molecular Genetics and New Jersey Medical School‐University Hospital Cancer Center, 205 South Orange Avenue, Cancer Center G1226, Newark, NJ 07101, USA
Abstract:
Keywords:mitochondria  oxidative stress  senescence  telomerase
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