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Inactivation of presenilins causes pre‐synaptic impairment prior to post‐synaptic dysfunction
Authors:Dawei Zhang  Chen Zhang  Angela Ho  Alfredo Kirkwood  Thomas C. Südhof  Jie Shen
Affiliation:1. Center for Neurologic Diseases, Brigham and Women’s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA;2. These authors contributed equally to this study.;3. Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, California, USA;4. Department of Biology, Boston University, Boston, Massachusetts, USA;5. Mind/Brain Institute, Johns Hopkins University, Baltimore, Maryland, USA
Abstract:
Keywords:Alzheimer’  s disease  conditional knockout  LTP  neurodegeneration  neurotransmitter release  NMDA receptor  synaptic dysfunction  synaptic facilitation
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