SIR2-induced inviability is suppressed by histone H4 overexpression |
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| Authors: | Matecic Mirela Stuart Shelagh Holmes Scott G |
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| Affiliation: | Department of Molecular Biology and Biochemistry, Wesleyan University, Middletown, Connecticut 06459, USA. |
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| Abstract: | We have identified histone H4 as a high-expression suppressor of Sir2-induced inviability in yeast cells. Overexpression of histone H3 does not suppress Sir2-induced lethality, nor does overexpression of histone H4 alleles associated with silencing defects. These results suggest a direct and specific interaction between Sir2 and H4 in the silencing mechanism. |
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