The cerulenin-induced formation of 1-acyl-lysophosphatidyl glycerol in Bacillus megaterium. |
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Authors: | S L Chen A J Fulco |
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Institution: | Department of Biological Chemistry, UCLA Medical School, and the Laboratory of Nuclear Medicine and Radiation Biology, University of California, Los Angeles, CA 90024 USA |
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Abstract: | When a culture of ATCC 14581, growing at 20° and treated with the fatty acid synthesis inhibitor, cerulenin, was incubated with U-14C]palmitate, 50% of the incorporated label was found in 1-palmitoyl-lysophosphatidyl glycerol within 5 min. Most of the remaining 14C appeared in free fatty acid and phosphatidyl glycerol. By 45 min almost all of the lyso compound had disappeared and 80% of the incorporated label was found in phosphatidyl glycerol. At 20°, in the absence of cerulenin or at 35° in either its presence or absence, no labeled lysophosphatidyl glycerol could be found at any time after U-14C]palmitate addition. The major radioactive lipid, in these cases, was always phosphatidyl glycerol. At 20°, the palmitate of phosphatidyl glycerol but not of lysophosphatidyl glycerol was readily desaturated. |
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