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A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection |
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| Authors: | Nicholson George Rantalainen Mattias Li Jia V Maher Anthony D Malmodin Daniel Ahmadi Kourosh R Faber Johan H Barrett Amy Min Josine L Rayner N William Toft Henrik Krestyaninova Maria Viksna Juris Neogi Sudeshna Guha Dumas Marc-Emmanuel Sarkans Ugis;MolPAGE Consortium Donnelly Peter Illig Thomas Adamski Jerzy Suhre Karsten Allen Maxine Zondervan Krina T Spector Tim D Nicholson Jeremy K Lindon John C Baunsgaard Dorrit Holmes Elaine McCarthy Mark I Holmes Chris C |
| Institution: | Department of Statistics, University of Oxford, Oxford, United Kingdom. nicholso@stats.ox.ac.uk |
| Abstract: | We have performed a metabolite quantitative trait locus (mQTL) study of the (1)H nuclear magnetic resonance spectroscopy ((1)H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. Urine and plasma samples were collected from two cohorts of individuals of European descent, with one cohort comprised of female twins donating samples longitudinally. Sample metabolite concentrations were quantified by (1)H NMR and tested for association with genome-wide single-nucleotide polymorphisms (SNPs). Four metabolites' concentrations exhibited significant, replicable association with SNP variation (8.6×10(-11) |
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