The effects of taxol on microtubular arrays: in vivo effects on heliozoan axonemes |
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| Authors: | K Hausmann M Linnenbach D J Patterson |
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| Affiliation: | 1. Department of Medicine, McGill University, Canada;2. Division of Clinical Epidemiology, McGill University Health Centre – Research Institute, Canada;3. Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Canada;4. Lady Davis Institute, Department of Psychiatry, Jewish General Hospital and McGill University, Canada |
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| Abstract: | The effects of the antitumor drug taxol on the microtubular axonemes of the heliozoon Actinophrys sol have been investigated. The drug induces polymerization of microtubules as shown by a large increase in the length and number of microtubular arrays. The interaction between microtubules and microtubule-associated proteins is also affected, with the result that the normal geometric patterning within the microtubular arrays is disturbed. This is due to the loss or inactivation of long intermicrotubule links. As a result, arms lose their rigidity. Because the drug stabilizes polymerized microtubules, C-shaped profiles and other signs of poor microtubule preservation are absent in taxol-treated cells. |
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