Mapping of new recessive cataract gene (itIr2) in the mouse |
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| Authors: | Chang-Woo Song Masaaki Okumoto Nobuko Mori Jin-Suk Kim San-Seop Han Kozaburo Esaki |
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| Institution: | (1) Laboratory of Experimental Animals, College of Agriculture, 1-1 Gakuen-cho, Sakai, Osaka 593, Japan, JP;(2) Division of Bionics, Department of Applied Bioscience, Research Institute of Advanced Science and Technology, Osaka Prefecture University, 1-2 Gakuen-cho, Sakai, Osaka 593, Japan, JP;(3) Department of Veterinary Medicine and Animal Resources Research Center, Kon Kuk University, 93-1, Mojin-dong, Kwangjin-ku, Seoul 133-701, Republic of Korea, KR;(4) Toxicological Research Center, Korea Research Institute of Chemical Technology, PO. Box 107, Yusung-gu, Taejeon-si 305-606, Republic of Korea, KR |
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| Abstract: | A new strain of mice with cataracts was developed in BALB/cHeA and STS/A recombinant inbred strain, CXS4 (D). In this study
the mapping of spontaneous autosomal recessive cataract mutation is described. This mutation was characterized by ruptures
of the lens nucleus, vitreous chamber through the posterior capsule, and the vacuolization of the lens. For the linkage analysis,
we produced two kinds of backcross progenies, (BALB/cHeA × D)F1 and (STS/A × D)F1 females crossed to D male mice. The gene (lr2, lens rupture2) was mapped to the central part of Chromosome(Chr) 14, 0.7 ± 0.7cM from the micosatellite marker D14Mit28.
Received: 13 October 1996 / Accepted: 22 July 1997 |
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