Neutrophil chemotactic activity of N-terminal peptides from the calpain small subunit |
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Authors: | M Kunimatsu X J Ma J Nishimura S Baba Y Hamada T Shioiri M Sasaki |
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Institution: | Department of Biochemistry, Nagoya City University Medical School, Japan. |
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Abstract: | On the basis of previous findings that N-acetyl nonapeptide from the human calpain I large subunit has chemotactic activity for neutrophils, a series of peptides with the N-terminal sequence of the calpain small subunit were synthesized and their chemotactic activity was examined. Potent activity was found in N-acetyl tetra, hepta, octa, nona and a larger peptide of 13 residues, although N-acetyl tripeptide showed only weak activity and N-acetyl penta and hexa peptides showed almost no activity. Since the small subunit is identical in calpains I and II, the results indicate that both calpains could be precursor proteins of chemotactic factors for neutrophils. |
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