首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Conserved regions at the DNA primase locus of IncP alpha and IncP beta plasmids
Authors:E Lanka  J P Fürste  E Yakobson  D G Guiney
Institution:1. Max-Planck-Institut für Molekulare Genetik, Abt. Schuster, D-1000 Berlin 33, Ihnestrasse 63 Germany;2. Department of Medicine H811F, University of California, San Diego, Medical Center, 225 Dickinson Street, San Diego, California 92103 USA
Abstract:Genes specifying DNA primases (pri) are common in all IncP plasmids examined so far. These plasmids suppress the thermosensitive character of the Escherichia coli dnaG3 mutation. The mechanism of suppression appears to be identical to that known for RP4 and IncI alpha plasmids. The DNA primases of both these plasmid types can substitute for the dnaG protein in chromosomal DNA replication. The pri genes of the alpha and beta subgroup of IncP plasmids are related to each other as judged from Southern hybridization and immunological data. Extensive DNA and protein sequence homology has been detected although the gene products of the alpha and beta subgroups exhibit substantial differences in size. The arrangement of overlapping genes at the pri locus of IncP alpha plasmids also appears to be present in the IncP beta group.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号