Computer simulation for effect of Pr(III) on Ca(II) speciation in human interstitial fluid |
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| Authors: | Zhang Haiyuan Lu Xing Wang Jinping Yang Kuiyue Niu Chunji |
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| Affiliation: | (1) Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 130022 Changchun, People’s Republic of China |
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| Abstract: | A mutiphase model of metal ion speciation in human interstitial fluid was constructed and the effect of Pr(III) on Ca(II) speciation was studied. Results show that Ca(II) mainly distributes in free Ca2+, [Ca(HCO3)], and [Ca(Lac)]. Because of the competition of Pr(III) for ligands with Ca(II), with the total concentration of Pr(III) rising, the percentages of free Ca2+, [Ca(Lac)] and [Ca(His)(Thr)H3], gradually increase and the percentages of CaHPO4(aq) and [Ca(Cit)(His)H2] gradually decrease. However, the percentages of [Ca(HCO3)] and CaCO3(aq) first increase, and then begin to decrease when the total concentration of Pr(III) exceeds 6.070×10−4 M. |
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| Keywords: | Computer simulation praseodymium(III) calcium(II) speciation human interstitial fluid |
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