INHIBITION OF 5''-NUCLEOTIDASE IN RAT BRAIN BY METHYLXANTHINES |
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| Authors: | Junji Tsuzuki R. W. Newburgh |
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| Affiliation: | Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, U.S.A. |
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| Abstract: | —Rat brain 5′-nucleotidase (EC 3.1.3.5) is inhibited by methylxanthines such as theophylline. Inhibition of the 5′-nucleotidase by theophylline appears more efficient than the inhibition of cAMP phosphodiesterase by this drug. A similar inhibition is observed with caffeine, theobromine, 7′-methyl-xanthine and 1-methylxanthine. |
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