Eukaryotic checkpoints are absent in the cell division cycle ofEntamoeba histolytica |
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Authors: | Sulagna Banerjee Suchismita Das Anuradha Lohia |
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Institution: | (1) Department of Biochemistry, Bose Institute, P1/12 CIT Scheme VIIM, 700 054 Kolkata, India |
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Abstract: | Fidelity in transmission of genetic characters is ensured by the faithful duplication of the genome, followed by equal segregation
of the genetic material in the progeny. Thus, alternation of DNA duplication (S-phase) and chromosome segregation during the
M-phase are hallmarks of most well studied eukaryotes. Several rounds of genome reduplication before chromosome segregation
upsets this cycle and leads to polyploidy. Polyploidy is often witnessed in cells prior to differentiation, in embryonic cells
or in diseases such as cancer. Studies on the protozoan parasite,Entamoeba histolytica suggest that in its proliferative phase, this organism may accumulate polyploid cells. It has also been shown that although
this organism contains sequence homologs of genes which are known to control the cell cycle of most eukaryotes, these genes
may be structurally altered and their equivalent function yet to be demonstrated in amoeba. The available information suggests
that surveillance mechanisms or ‘checkpoints’ which are known to regulate the eukaryotic cell cycle may be absent or altered
inE. histolytica. |
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Keywords: | Cell division cycle checkpoints Entamoeba histolytica genome reduplication polyploidy protozoan parasite |
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