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Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands |
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| Authors: | Chesworth Richard Wessel Matthew D Heyden Lisa Mangano F Michael Zawistoski Michael Gegnas Laura Galluzzo David Lefker Bruce Cameron Kimberly O Tickner Jeanne Lu Bihong Castleberry Tessa A Petersen Donna N Brault Amy Perry Pia Ng Oicheng Owen Thomas A Pan Lydia Ke Hua-Zhu Brown Thomas A Thompson David D DaSilva-Jardine Paul |
| Institution: | aCardiovascular and Metabolic Diseases, Medicinal Chemistry, Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA bComputational Chemistry, Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA cCardiovascular and Metabolic Diseases, Biology, Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA |
| Abstract: | A series of ligands with varying heterocyclic cores and substituents that display a range of selectivity’s (up to >100x) for ER-β over ER- are reported. |
| Keywords: | Estrogen receptor ER beta selective ligands |
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