Immune selective pressure and HLA class I antigen defects in malignant lesions |
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Authors: | Chien-Chung Chang Soldano Ferrone |
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Affiliation: | Department of Structural Biology, Hauptman-Woodward Institute, 700 Ellicott Street, Buffalo, NY 14203, USA. |
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Abstract: | The revived cancer immune surveillance theory has emphasized the active role the immune system plays in eliminating tumor cells and in facilitating the emergence of their immunoresistant variants. MHC class I molecule abnormalities represent, at least in part, the molecular phenotype of these escape variants, given the crucial role of MHC class I molecules in eliciting tumor antigen-specific T cell responses, the high frequency of HLA class I antigen abnormalities in malignant lesions and their association with a poor clinical course of the disease. Here, we present evidence for this possibility and review the potential mechanisms by which T cell selective pressure participates in the generation of tumor cells with MHC class I molecule defects. Furthermore, we discuss the strategies to counteract tumor cell immune evasion. |
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Keywords: | Darwin theory Immune surveillance Immune selection Immunoprevention Immunotherapy Malignant disease MHC class I antigens |
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