Effects of CuDIPS and tween 80 on SJL/J tumorigenesis |
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| Authors: | Charles G. Crispens Philip S. Porter John R. J. Sorenson |
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| Affiliation: | (1) Department of Biology, University of Alabama at Birmingham, University Station, 35294 Birmingham, Alabama;(2) Department of Medicinal Chemistry, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 W. Markham, 72205 Little Rock, Arkansas |
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| Abstract: | Plasma copper and zinc levels were measured in SJL/J mice, an inbred strain characterized by a high, spontaneous incidence of reticulum cell sarcoma (RCS). The changes with age in mean concentrations of these metals were consistent with a physiological response that is required for remission of neoplasia. Treatment of SJL/J mice with a copper complex, Cu(II)(3,4-diisopropylsalicylate)2 (Cu 3,5-DIPS), dissolved in a 10% Tween 80-saline solution revealed a decrease in survival and decline in the incidence of RCS at 52 wk of age. The toxic effects of Cu 3,5-DIPS therapy appeared to be related to the intraperitoneal route of administration and to extracellular deposition of collagen. The inhibitory effect on tumor development was not related to Cu 3,5-DIPS. Rather, Tween 80 was found to be the factor of importance. |
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| Keywords: | Copper copper complex toxicity reticulum cell sarcoma SJL/J mice Tween 80 zinc |
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