Baseline viral load and immune activation determine the extent of reconstitution of innate immune effectors in HIV-1-infected subjects undergoing antiretroviral treatment |
| |
Authors: | Chehimi Jihed Azzoni Livio Farabaugh Matthew Creer Shenoa A Tomescu Costin Hancock Aidan Mackiewicz Agnes D'Alessandro Lara Ghanekar Smita Foulkes Andrea S Mounzer Karam Kostman Jay Montaner Luis J |
| |
Institution: | HIV Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, PA 19104, USA. |
| |
Abstract: | We analyzed dendritic cell (DC) and NK cell compartments in relation to CD4 recovery in 21 HIV-infected subjects followed to <50 copies/ml once starting antiretroviral therapy (ART) and observed for 52 wk of sustained suppression. Although CD4 counts increased in all subjects in response to ART, we observed a restoration of functional plasmacytoid DC (PDC) after 52 wk of sustained suppression under ART (from 1850 cells/ml to 4550 cells/ml) to levels comparable to controls (5120 cells/ml) only in subjects with a low baseline viral load, which also rapidly suppressed to <50 copies/ml upon
|
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|