Cloning of the guinea pig 5-lipoxygenase gene and nucleotide sequence of its promoter. |
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| Authors: | A Chopra D L Ferreira-Alves P Sirois J P Thirion |
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| Affiliation: | Department of Microbiology, Faculty of Medicine, University of Sherbrooke, Canada. |
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| Abstract: | The guinea pig 5-lipoxygenase (5-LO) gene and its promoter were cloned from a guinea pig genomic DNA library. Sequencing analysis of the guinea pig promoter revealed that expression of the 5-LO gene in this rodent is probably governed by cis acting nucleotide sequences quite similar to the human gene. Nucleotide sequences that bind factors like Sp-1, AP-2, NF-kB and c-Ha-ras were identified in the guinea pig 5-LO promoter region. |
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