Interferon gamma does not induce antiviral resistance in T lymphocytes |
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| Authors: | M Zucca G Gribaudo B Ferrara G Cavallo S Landolfo |
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| Institution: | Institute of Microbiology, University, Torino, Italy. |
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| Abstract: | We compared the activity of human recombinant alpha and gamma interferons (IFNs) on normal T lymphocytes and various T cell lines. IFN gamma, unlike IFN alpha, did not promote the antiviral state in these cells, or induce the activity of 2'-5' oligoadenylate synthetase. The lack of antiviral effect was observed using an RNA virus (VSV) and a DNA virus (HSV, type 1) as challenger viruses. |
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