Uncoupling protein 2: a novel player in neuroprotection |
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Authors: | Paradis Eric Clavel Sébastien Bouillaud Frédéric Ricquier Daniel Richard Denis |
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Affiliation: | Centre de Recherche de l'H?pital Laval (Institut universitaire de Cardiologie et de Pneumologie) et Faculté de Médecine de l'Université Laval, Québec, Canada G1K 7P4. |
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Abstract: | A recent report provides exciting new evidence that suggests that uncoupling protein 2 (UCP2), a mitochondrial protein expressed in specific cells of numerous tissues, might be neuroprotective by reducing mitochondrial Ca2+ uptake and preventing mitochondrial accumulation of reactive oxygen species (ROS) following cerebral ischemia. The mitochondrial sequestration of Ca2+ and ROS, which depends on the mitochondrial membrane potential (ΔΨm), is a deleterious consequence of excitotoxicity. A neuroprotective role for Ucp2 is consistent with the already proposed property of this gene in mitigating cellular damage caused by ROS. |
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