Mouse models for the genetic study of tuberculosis susceptibility. |
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Authors: | Tania Di Pietrantonio Erwin Schurr |
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Affiliation: | McGill University Health Centre Research Institute, 1650 Cedar Ave, L11-520, Montreal, PQ, H3G 1A4, Canada. |
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Abstract: | Tuberculosis, mainly caused by the pathogenic bacterium Mycobacterium tuberculosis, remains an inestimable public health problem, despite the established use of the Bacillus Calmette-Guerin (BCG) vaccine, multidrug therapy and the existence of global tuberculosis control programmes. Statistics show that nearly 2 billion people (approximately one-third of the world's population) are infected with M. tuberculosis. For unknown reasons, only about 10 per cent of those infected by M. tuberculosis will develop tuberculosis, resulting in 9 million new cases yearly and 2 million deaths. A better understanding of the host--mycobacterial--environmental interplay is central to developing better antituberculosis vaccines and treatments. This review will discuss how a clearer idea of this interplay is emerging with new genomic strategies in mouse models. |
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Keywords: | Mycobacterium tuberculosis mice reverse genetics forward genetics quantitative trait loci (QTL) susceptibility |
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