The PhoBR two-component system regulates antibiotic biosynthesis in Serratia in response to phosphate |
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| Authors: | Tamzin Gristwood Peter C Fineran Lee Everson Neil R Williamson and George P Salmond |
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| Institution: | (1) Department of Biochemistry, University of Cambridge, CB2 1QW Cambridge, UK;(2) Current address: Department of Microbiology & Immunology, University of Otago, PO Box 56, Dunedin, New Zealand |
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| Abstract: | Background Secondary metabolism in Serratia sp. ATCC 39006 (Serratia 39006) is controlled via a complex network of regulators, including a LuxIR-type (SmaIR) quorum sensing (QS) system. Here
we investigate the molecular mechanism by which phosphate limitation controls biosynthesis of two antibiotic secondary metabolites,
prodigiosin and carbapenem, in Serratia 39006. |
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