Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos |
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| Authors: | Christopher J Wilkinson Matthias Carl William A Harris |
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| Affiliation: | (1) Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK;(2) Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK;(3) School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey, TW20 0EX, UK;(4) Department of Cell and Molecular Biology, Faculty of Medicine Mannheim, University of Heidelberg, 68167 Mannheim, Germany |
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| Abstract: | Background The centrosome is the cell's microtubule organising centre, an organelle with important roles in cell division, migration and polarity. However, cells can divide and flies can, for a large part of development, develop without them. Many centrosome proteins have been identified but the roles of most are still poorly understood. The centrioles of the centrosome are similar to the basal bodies of cilia, hair-like extensions of many cells that have important roles in cell signalling and development. In a number of human diseases, such Bardet-Biedl syndrome, centrosome/cilium proteins are mutated, leading to polycystic kidney disease, situs inversus, and neurological problems, amongst other symptoms. |
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