Fe(II) phthalocyanine catalyzed oxidation of dGMP by molecular oxygen |
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| Authors: | Aleksandra A Kuznetsova Lyudmila I Solovyeva Oleg L Kaliya Evgeniy A Lukyanets Dmitri G Knorre Olga S Fedorova |
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| Institution: | 1. Novosibirsk State University, 630090 Novosibirsk, Russia;2. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia;3. State Research Centre ‘Organic Intermediates and Dyes Institute’ (SRC ‘NIOPIK’), 103787 Moscow, Russia |
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| Abstract: | We show that iron(II)-phthalocyanines are able to catalyze guanosine oxidation by molecular oxygen in the presence of reducing agents such as ascorbic acid and 2-mercaptoethanol. The products of 5′-monophosphate-2′-deoxyguanosine (dGMP) oxidation were directly analyzed using the HPLC-ESI/MS method. The main oxidation products were 5′-phospho-2′-deoxy-8-oxo-7,8-dihydroguanine and the 1,N2-glyoxal adduct of the 5′-monophosphate-2′-deoxyguanosine. |
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