Dosage analysis of Z chromosome genes using microarray in silkworm,Bombyx mori |
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| Authors: | Xingfu Zha Qingyou Xia Jun Duan Chunyun Wang Ningjia He Zhonghuai Xiang |
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| Affiliation: | 1. The Key Sericultural Laboratory of Agricultural Ministry, College of Biotechnology, Southwest University, Beibei, Chongqing 400715, China;2. The Institute of Agronomy and Life Sciences, Chongqing University, Chongqing 400030, China;1. Faculty of Life Sciences, Northwestern Polytechnical University, Xi''an 710072, China;2. Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China;3. University of Chinese Academy of Sciences, Beijing 100049, China;4. Division of Plant Sciences, University of Missouri, Columbia, MO, USA;1. Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan;2. National Institute of Agrobiological Sciences, Tsukuba, Japan;3. Institute of Genetic Resources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan;1. Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China;2. Graduate School of Southwest Medical University, Luzhou, China;3. Department of Radiology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China |
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| Abstract: | In many organisms, dosage compensation is needed to equalize sex-chromosome gene expression in males and females. Several genes on silkworm Z chromosome were previously detected to show a higher expression level in males and lacked dosage compensation. Whether silkworm lacks global dosage compensation still remains poorly known. Here, we analyzed male:female (M:F) ratios of expression of chromosome-wide Z-linked genes in the silkworm using microarray data. The expression levels of genes on Z chromosome in each tissue were significantly higher in males compared to females, which indicates no global dosage compensation in silkworm. Interestingly, we also found some genes with no bias (M:F ratio: 0.8–1.2) on the Z chromosome. Comparison of male-biased (M:F ratio more than 1.5) and unbiased genes indicated that the two sets of the genes have functional differences. Analysis of gene expression by sex showed that M:F ratios were, to some extent, associated with their expression levels. These results provide useful clues to further understanding roles of dosage of Z chromosome and some Z-linked sexual differences in silkworms. |
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