Synthesis and biological evaluation of new heterocyclic quinolinones as anti-parasite and anti-HIV drug candidates |
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| Authors: | Albert Darque Aurélien Dumètre Sébastien Hutter Gilles Casano Maxime Robin Christophe Pannecouque Nadine Azas |
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| Affiliation: | 1. UMR-MD3—Relations Hôte-Parasites, Pharmacologie et Thérapeutique, Faculté de Pharmacie, Université de la Méditerranée, Marseille Cedex 05, France;2. Institut des Sciences Moléculaire de Marseille, iSm2 CNRS UMR 6263, Aix-Marseille Universités, Centre de St. Jérôme, Service 552, 13397 Marseille Cedex 20, France;3. Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium |
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| Abstract: | We have synthesized quinolinones with potential antiparasitic and anti-HIV activities by an original two-step method involving microwave irradiation and have evaluated their activities against Plasmodium falciparum, Leishmania donovani, Trichomonas vaginalis, and HIV. None of the tested compounds had been previously described using this method of synthesis. One of the compounds had interesting antiparasitic and anti-HIV activity, which could be improved by substitution with different radicals. |
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