Synthesis of a series of novel dihydroartemisinin derivatives containing a substituted chalcone with greater cytotoxic effects in leukemia cells |
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| Authors: | Xuelin Yang Wei Wang Jun Tan Dandan Song Ming Li Dan Liu Yongkui Jing Linxiang Zhao |
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| Institution: | 1. Shenyang Pharmaceutical University, Shenyang 110016, PR China;2. Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA |
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| Abstract: | Fifteen dihydroartemisinin derivatives containing a substituted chalcone linked by either ether or ester were synthesized and investigated for their cytotoxicity in human leukemia HL-60 and mouse lymphoma P388 cells. These derivatives have greater antiproliferative and cytotoxic effects in both cell lines than dihydroartemisinin. Dihydroartemisinin chalcones linked by ether are more cytotoxic than dihydroartemisinin chalcones linked by ester with apoptosis induction abilities. |
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