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Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3) |
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| Authors: | Scott D Kuduk Ronald K Chang Jenny M-C Wai Christina N Di Marco Victoria Cofre Robert M DiPardo Sean P Cook Matthew J Cato Aneta Jovanovska Mark O Urban Michael Leitl Robert H Spencer Stefanie A Kane George D Hartman Mark T Bilodeau |
| Institution: | 1. Department of Medicinal Chemistry, Sumneytown Pike, PO Box 4, West Point, PA 19486, USA;2. Department Pain Research Merck Research Laboratories, Sumneytown Pike, PO Box 4, West Point, PA 19486, USA |
| Abstract: | A series of indole amidines modified at the 2-position of the indole ring were evaluated as inhibitors of Acid-Sensing Ion Channel-3 (ASIC3), a novel target for the treatment of chronic pain. |
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