Synthesis of 1,6,7,8-tetrahydro-naphtho[2,3-d]-azepino[4,5-b]indole-9,14-diones and their inhibitory effects on pro-inflammatory cytokines |
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| Authors: | Waya S. Phutdhawong Wanwikar Ruensamran Weerachai Phutdhawong Thongchai Taechowisan |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, Silpakorn University, Nakorn Pathom 73000, Thailand;2. Department of Chemistry, Faculty of Liberal Arts and Science, Kasetsart University, Kampang Saen Campus, Nakhon Pathom 73140, Thailand;3. Research Promotion and Technology Transfer Center, Faculty of Liberal Arts and Science, Kasetsart University, Kampang Saen Campus, Nakhon Pathom 73140, Thailand;4. Department of Microbiology, Faculty of Science, Silpakorn University, Nakhon Pathom 73000, Thailand |
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| Abstract: | A rapid route to a series of naphthoquinone-fused indole derivatives via irradiation in a modified commercial domestic microwave is reported. The desired products were produced in high yields and short reaction times. The naphthoquinone-fused indole derivatives were evaluated for their pro-inflammatory cytokines responses using lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophages. The results showed that most of the tested compounds inhibit the production of nitric oxide (NO), prostaglandin (PG)E2, tumour necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β in RAW264.7 cells treated with LPS. |
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