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Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system |
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| Authors: | Robert O Hughes John K Walker Jerry W Cubbage Yvette M Fobian D Joseph Rogier Steve E Heasley Rhadika M Blevis-Bal Alan G Benson Dafydd R Owen E Jon Jacobsen John N Freskos John M Molyneaux David L Brown William C Stallings Brad A Acker Todd M Maddux Mike B Tollefson Jennifer M Williams Joseph B Moon Brent V Mischke Ying Yu |
| Institution: | 1. Pfizer Global Research and Development, Chesterfield Parkway West, St. Louis, MO 63017, USA;2. Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK |
| Abstract: | Efforts to improve the potency and physical properties of the aminopyridiopyrazinone class of PDE5 inhibitors through modification of the core ring system are described. Five new ring systems are evaluated and features that impart improved potency and improved solubility are delineated. |
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