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Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists |
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| Authors: | Alexander Pasternak Stephen D. Goble Reynalda K. deJesus Donna L. Hreniuk Christine C. Chung Michael R. Tota Paul Mazur Scott D. Feighner Andrew D. Howard Sander G. Mills Lihu Yang |
| Affiliation: | Merck Research Laboratories, Rahway, NJ 07065, USA |
| Abstract: | This Letter describes optimization of ghrelin receptor antagonists and inverse agonists starting from a screening hit. |
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