Synthesis of 9-β-d-arabinofuranosylguanine by combined use of two whole cell biocatalysts |
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Authors: | Rosario Médici Adolfo M. Iribarren Elizabeth S. Lewkowicz |
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Affiliation: | 1. Biotransformations Laboratory, Universidad Nacional de Quilmes. R.S. Peña 352, 1876 Bernal, Buenos Aires, Argentina;2. INGEBI, CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina |
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Abstract: | Unlike the preparation of other purine nucleosides, transglycosylation from a pyrimidine nucleoside and guanine is difficult because of the low solubility of this base. Thus, another strategy, based on the coupled action of two whole cell biocatalyzed reactions, transglycosylation and deamination, was used. Enterobacter gergoviae and Arthrobacter oxydans were employed to synthesize 9-β-d-arabinofuranosylguanine (AraG), an efficient anti leukemic drug. |
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