Evaluation of triazolamers as active site inhibitors of HIV-1 protease |
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| Authors: | Andrea L Jochim Stephen E Miller Nicholas G Angelo Paramjit S Arora |
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| Institution: | Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA |
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| Abstract: | Proteases typically recognize their peptide substrates in extended conformations. General approaches for designing protease inhibitors often consist of peptidomimetics that feature this conformation. Herein we discuss a combination of computational and experimental studies to evaluate the potential of triazole-linked β-strand mimetics as inhibitors of HIV-1 protease activity. |
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