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Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors |
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| Authors: | Yoshiyuki Sato Yu Onozaki Tetsuya Sugimoto Hideki Kurihara Kaori Kamijo Chie Kadowaki Toshiaki Tsujino Akiko Watanabe Sachie Otsuki Morihiro Mitsuya Masato Iida Kyosuke Haze Takumitsu Machida Yoko Nakatsuru Hideya Komatani Hidehito Kotani Yoshikazu Iwasawa |
| Institution: | Banyu Tsukuba Research Institute, Merck Research Laboratories, Banyu Pharmaceutical Co., Ltd, Okubo-3, Tsukuba, Ibaraki 300-2611, Japan |
| Abstract: | A novel class of imidazopyridine derivatives was designed as PLK1 inhibitors. Extensive SAR studies supported by molecular modeling afforded a highly potent and selective compound 36. Compound 36 demonstrated good antitumor efficacy in xenograft nude rat model. |
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