Solid phase synthesis of acylglycine human metabolites |
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Authors: | Rolando Perez-Pineiro Ying Wei Dong David S. Wishart |
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Affiliation: | 1. Department of Biological Sciences, University of Alberta, Edmonton AB, Canada T6G 2E9;2. Department of Computing Science, University of Alberta, Edmonton AB, Canada T6G 2E9 |
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Abstract: | Acylglycines represents a large and important class of human metabolites. They are often used in medicine to identify fatty acid oxidation disorders. A highly efficient solid phase synthesis approach to obtain these clinically important compounds is developed via coupling reaction between glycine-preloaded Wang resin and a set of carboxylic acids. The developed methodology facilitates the preparation of several structurally-diverse acylglycines with high yields and purity. |
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