|
|||||
|
|
Discovery of CYT997: a structurally novel orally active microtubule targeting agent |
|
| Authors: | Christopher J Burns Michael F Harte Xianyong Bu Emmanuelle Fantino Max Joffe Harrison Sikanyika Stephen Su C Elisabet Tranberg Neil Wilson Susan A Charman David M Shackleford Andrew F Wilks |
| Institution: | 1. Cytopia Research Pty Ltd, 576 Swan St, Richmond, VIC 3121, Australia;2. Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia |
| Abstract: | CYT997 was discovered as a potent tubulin polymerization inhibitor possessing potent cytotoxic activity against a range of cancer cells. Details of SAR studies, pharmacokinetic investigations and synthesis of compounds leading to the discovery of CYT997 are reported. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |