Pyrazolopyrimidines and pyrazolotriazines with potent activity against herpesviruses |
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| Authors: | Kristjan S Gudmundsson Brian A Johns Jason Weatherhead |
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| Institution: | Department of Medicinal Chemistry, Metabolic and Virology Center of Excellence for Drug Discovery, GlaxoSmithKline Research & Development, Five Moore Drive, Research Triangle Park, NC 27709-3398, USA |
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| Abstract: | Synthesis of several pyrazolo1,5-c]pyrimidines, pyrazolo1,5-a]pyrimidines and pyrazolo1,5-a]1,3,5]triazines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar or better than acyclovir are described. |
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