Puupehanol,a sesquiterpene-dihydroquinone derivative from the marine sponge Hyrtios sp. |
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| Authors: | Wen-Hui Xu Yuanqing Ding Melissa R Jacob Ameeta K Agarwal Alice M Clark Daneel Ferreira Zong-Suo Liang Xing-Cong Li |
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| Institution: | 1. National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA;2. College of Life Sciences, Northwest A & F University, Yangling, Shaanxi 712100, People’s Republic of China;3. Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA |
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| Abstract: | Puupehanol (1), a new sesquiterpene-dihydroquinone derivative, was isolated from the marine sponge Hyrtios sp., along with the known compounds puupehenone (2) and chloropuupehenone (3) that are responsible for the antifungal activity observed in the extract. The structure of 1 was established as (20R,21R)-21-hydroxy-20,21-dihydropuupehenone by extensive spectroscopic and computational methods. Compound 2 exhibited potent activity against Cryptococcus neoformans and Candida krusei with MFCs of 1.25 and 2.50 μg/mL, respectively. |
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