Synthesis and antitumor activity of substituted triazolo[4,3-a]pyrimidin-6-sulfonamide with an incorporated thiazolidinone moiety |
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Authors: | Hend N. Hafez Abdel-Rahman B.A. El-Gazzar |
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Affiliation: | National Research Centre, Photochemistry Department (Heterocyclic & Nucleoside Unit), Dokki, 12622 Cairo, Egypt |
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Abstract: | Chlorosulfonation of 3-methyl[1,2,4]triazolo[4,3-a]pyrimidine with chlorosulfonic acid in the presence of thionyl chloride was studied. When triazolo[4,3-a]pyrimidines are used as substrates, the substitution occurs at C-6. Also the reactivity of the hydrazides (7) towards aldehydes, thioglycolic acid and amines were studies. The newly prepared compounds 10a,d and 11a,d demonstrated inhibitory effects on the growth of a wide range of cancer cell lines generally at 10?5 M level and in some cases at 10?7 M concentrations. |
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