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New classes of potent and bioavailable human renin inhibitors |
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| Authors: | L’uboš Remeň Olivier Bezençon Sylvia Richard-Bildstein Daniel Bur Lars Prade Olivier Corminboeuf Christoph Boss Corinna Grisostomi Thierry Sifferlen Panja Strickner Patrick Hess Stéphane Delahaye Alexander Treiber Thomas Weller Christoph Binkert Beat Steiner Walter Fischli |
| Affiliation: | Drug Discovery and Preclinical Research, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland |
| Abstract: | New classes of de novo designed renin inhibitors are reported. Some of these compounds display excellent in vitro and in vivo activities toward human renin in a TGR model. The synthesis of these new types of mono- and bicyclic scaffolds are reported, and properties of selected compounds discussed. |
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