Synthesis and anticancer activity of novel 3,4-diarylthiazol-2(3H)-ones (imines) |
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| Authors: | Zong-Ying Liu Yue-Ming Wang Zhuo-Rong Li Jian-Dong Jiang David W Boykin |
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| Institution: | 1. Department of Chemistry, Georgia State University, Atlanta, GA 30303-3083, USA;2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, People’s Republic of China |
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| Abstract: | A series of 3,4-diarylthiazol-2(3H)-ones and three 3,4-diarylthiazol-2(3H)-imines were synthesized and evaluated for their cytotoxicity in a panel of human cancer cell lines. Compounds 21 and 22 showed potential anticancer activity against human CEM cells with IC50 values of 0.12 and 0.24 μM, respectively. |
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