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Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs) |
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| Authors: | Christopher J Burns David G Bourke Laura Andrau Xianyong Bu Susan A Charman Andrew C Donohue Emmanuelle Fantino Michelle Farrugia John T Feutrill Max Joffe Marcel R Kling Margarita Kurek Tracy L Nero Thao Nguyen James T Palmer Ian Phillips David M Shackleford Harrison Sikanyika Michelle Styles Stephen Su Andrew F Wilks |
| Institution: | 1. Cytopia Research Pty Ltd, 576 Swan St, Richmond, VIC 3121, Australia;2. Centre for Drug Candidate Optimisation, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Pde, Parkville, VIC 3052, Australia |
| Abstract: | A series of phenylaminopyrimidines has been identified as inhibitors of Janus kinases (JAKs). Development of this initial series led to the potent JAK2/JAK1 inhibitor CYT387 (N-(cyanomethyl)-4-2-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-benzamide). Details of synthesis and SAR studies of these compounds are reported. |
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