Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: Part 2 |
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| Authors: | Mark Andrews Alan Brown Jean-Yves Chiva David Fradet David Gordon Mark Lansdell Malcolm MacKenny |
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| Institution: | Discovery Chemistry, Pfizer Global Research and Development, Sandwich, United Kingdom |
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| Abstract: | A second wave of potential SSRIs with high ease of synthetic accessibility were designed based on the reported selective serotonin re-uptake inhibitor litoxetine and our own previous work in this area. Preparation and subsequent optimisation yielded a range of potent and highly selective SSRIs. |
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