C29 sterols with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge Ianthella sp. and their anticancer properties |
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| Authors: | Nguyen Huu Tung Chau Van Minh Tran Thu Ha Phan Van Kiem Hoang Thanh Huong Nguyen Tien Dat Nguyen Xuan Nhiem Bui Huu Tai Jae-Hee Hyun Hee-Kyoung Kang Young Ho Kim |
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| Institution: | 1. College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea;2. Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Viet Nam;3. School of Medicine, Institute of Medical Sciences, Jeju National University, Jeju 690-756, Republic of Korea |
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| Abstract: | Two new C29 sterols with a cyclopropane ring at C-25 and C-26, petrosterol-3,6-dione (1) and 5α,6α-epoxy-petrosterol (2), along with petrosterol (3), were isolated from the Vietnamese marine sponge Ianthella sp. The structures of the new compounds were elucidated by comprehensive spectroscopic analyses. Compounds 1?3 showed cytotoxic activities on A549, HL-60, MCF-7, SK-OV-3, and U937 cancer cell lines with IC50 in the range of 8.4–22.6 μM, whereas compounds 1?3 exhibited only weak cytotoxic activities on HT-29 cell. After HL-60 cells were treated with the compounds, several apoptosis events like chromatin condensation and the increase of the population of sub-G1 hypodiploid cells were observed. These data supported that the compounds might have potential for leukemia treatment. |
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