Role of prostaglandins on the regulation of macrophage proliferation and cytotoxic functions |
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| Authors: | HG Meerpohl T Bauknecht |
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| Institution: | 1. Department of General Surgery, Fourth Affiliated Hospital of Harbin Medical University, Harbin, China;2. Department of Neurosurgery, Fourth Affiliated Hospital of Harbin Medical University, Harbin, China;1. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China;2. State Key Laboratory of Maternal and Fetal Medicine of Chongqing, Chongqing Medical University, Chongqing 400016, China;3. The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, Chongqing Medical University, Chongqing 400016, China;4. Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China;1. College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea;2. College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea;3. College of Pharmacy, Gachon University, Incheon 21963, Republic of Korea;4. Korea Mouse Phenotyping Center, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea |
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| Abstract: | The data presented show different effects of prostaglandins on proliferation and cytotoxic effector functions of murine bone-marrow derived mononuclear cells. Colony stimulating factor (CSF)-dependent proliferation of colony forming unit-cells (CFU c) was inhibited by PGE1, PGE2 and PGB2. Lymphokine induced cytotoxicity and antibody mediated cytotoxicity (ADCC) of monocytes and macrophages were also affected by PG. We conclude that PGE2 may regulate macrophage mediated tumorcell-lysis mainly at the induction phase.If there processes function in vivo, one would therefore expect high affinity binding sites for PGE2 on macrophages. The existence of a receptor for PGE2 one murine bone marrow derived macrophages is described. |
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