Population-Genetic Structure of Chuvash Populations Inferred from the Data on Eight DNA Loci of the Nuclear Genome |
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| Authors: | E K Khusnutdinova T V Victorova V L Akhmetova O E Mustafina R I Fatkhlislamova E V Balanovskaya N V Petrova S V Makarov O I Kravchuk G V Pai E K Ginter |
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| Institution: | (1) Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences, Ufa, 450054, Russia;(2) Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow, 115478, Russia |
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| Abstract: | Population-genetic study of indigenous populations representing three ethnic Chuvash group: highland (Cheboksarsk and Morgaush district), lowland (Kanash district) and mid-lowland (Marposad district). Eight polymorphic DNA loci of the nuclear genome (VNTR/PAH, STR/PAH, VNTR/ApoB, VNTR/DAT1, APF, VNTR/eNOS, IVS6aGATT, and KM.19/PstI) were examined in the population of each district. For each of the four population, we estimated the allele and genotype frequency distributions at each polymorphic system, heterozygosities H
S and between-population differences F
ST. In the combined Chuvash sample,
= 0.464 and
= 0.006. Loci VNTR(DAT) and VNTR(ApoB) showed highest between-population differentiation (0.009  F
ST 0.012), and loci IVS6aGATT, APF, VNTR(eNOS), andD7S23(KM.19), lowest differentiation (0.001 F
ST 0.003). Analysis of genetic distances revealed somewhat higher genetic similarity between the Cheboksarsk and Morgaush populations belonging to the highland Chuvash group, whereas the highland Chuvash population from the Marposad district, which belong to the mid-lowland group, was more distant from the former populations. |
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