| 酶法制备羟甲基戊二酰CoA还原酶抑制剂手性中间体的研究进展 |
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| 引用本文： | 汪钊,赵冉冉,应向贤,郭跃平. 酶法制备羟甲基戊二酰CoA还原酶抑制剂手性中间体的研究进展[J]. 生物加工过程, 2010, 8(1): 72-77 |
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| 作者姓名： | 汪钊 赵冉冉 应向贤 郭跃平 |
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| 作者单位： | 浙江工业大学,生物与环境工程学院,杭州,310014 |
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| 基金项目： | 浙江省重大科技资助项目 |
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| 摘 要： | 羟甲基戊二酰CoA(HMG-CoA)还原酶抑制剂是降血脂药物。综述了近年来国内外酶法制备HMG-CoA还原酶抑制剂手性中间体的研究进展,从不对称合成和外消旋体拆分2个方面介绍了酶法制备HMG-CoA还原酶抑制剂手性中间体的工艺路线和研究水平,对其工业化前景进行了展望。
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| 关 键 词： | 不对称合成 HMG—CoA 抑制剂 还原酶 拆分 |
Development of enzymatic synthesis of chiral intermediates for HMG-CoA reductase inhibitors |
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| WANG Zhao,ZHAO Ran-ran,YING Xiang-xian,GUO Yue-ping. Development of enzymatic synthesis of chiral intermediates for HMG-CoA reductase inhibitors[J]. Chinese Journal of Bioprocess Engineering, 2010, 8(1): 72-77 |
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| Authors: | WANG Zhao ZHAO Ran-ran YING Xiang-xian GUO Yue-ping |
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| Affiliation: | WANG Zhao,ZHAO Ran-ran,YING Xiang-xian,GUO Yue-ping(College of Biological , Environmental Engineering,Zhejiang University of Technology,Hangzhou 310014,China) |
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| Abstract: | Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A(HMG-CoA) reductase were used as hypolipidemic drugs.The progress for enzymatic synthesis of chiral intermediates for HMG-CoA reductase inhibitors was reviewed,particularly in the perspectives of asymmetric synthesis and racemates resolution.The application prospective of the intermediates in industry was also discussed. |
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| Keywords: | HMG-CoA asymmetric synthesis HMG-CoA inhibitors reductase resolution |
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