Involvement of gicerin, a cell adhesion molecule, in development and regeneration of chick sciatic nerve |
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Authors: | Hiroi Satoshi Tsukamoto Yasuhiro Sasaki Fumihiko Miki Naomasa Taira Eiichi |
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Affiliation: | Department of Veterinary Anatomy, Osaka Prefecture University, Graduate School of Agriculture and Biological Sciences, 1-1 Gakuencho, Sakai, Osaka 599-8531, Japan. |
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Abstract: | We have examined the role of gicerin, an immunoglobulin superfamily cell adhesion molecule, in chick sciatic nerves during development and regeneration. Gicerin was expressed in the spinal cord, dorsal root ganglion (DRG) and sciatic nerves in embryos, but declined after hatching. Neurite extensions from explant cultures of the DRG were promoted on gicerin's ligands, which were inhibited by an anti-gicerin antibody. Furthermore, gicerin expression was upregulated in the regenerating sciatic nerves, DRG and dorsal horn of the spinal cord after injury to the sciatic nerve. These results indicate that gicerin might participate in the development and regeneration of sciatic nerves. |
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Keywords: | Gicerin Cell adhesion molecule Sciatic nerve Development Regeneration Neurite outgrowth factor |
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