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Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains |
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| Authors: | Blizzard Timothy A DiNinno Frank Morgan Jerry D Wu Jane Y Chen Helen Y Kim Seongkon Chan Wanda Birzin Elizabeth T Yang Yi Tien Pai Lee-Yuh Zhang Zhoupeng Hayes Edward C DaSilva Carolyn A Tang Wei Rohrer Susan P Schaeffer James M Hammond Milton L |
| Affiliation: | Merck Research Laboratories, Medicinal Chemistry, RY800-B116, PO Box 2000, Rahway, NJ 07065, USA. tim_blizzard@merck.com |
| Abstract: | A series of benzoxathiin SERAMs with heteroatom-substituted amine side chains was prepared. Minor modifications in the side chain resulted in significant effects on biological activity, especially in uterine tissue. |
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